Protein Name: Lethal(2) giant larvae protein homolog 1
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UniprotKB/SwissProt ID: L2GL1_HUMAN (Q15334)
Gene Name: LLGL1
Synonyms: DLG4, HUGL, HUGL1
Organism: Homo sapiens (Human).
Function: Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Early endosome membrane (By similarity). Golgi apparatus, trans-Golgi network membrane (By similarity). Golgi apparatus membrane (By similarity). Cell projection, axon (By similarity). Cytoplasm, cytoskeleton. Note=Localized to the lateral membrane durin
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Protein disease:
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Disease database |
Database Entry |
Disease information | OMIM | 600966 | LETHAL GIANT LARVAE, DROSOPHILA, HOMOLOG OF, 1; LLGL1 ;;LLGL;; HUGL1;; DLG4, FORMERLY |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
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