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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Lethal(2) giant larvae protein homolog 1

UniprotKB/SwissProt ID: L2GL1_HUMAN (Q15334)

Gene Name: LLGL1

Synonyms: DLG4, HUGL, HUGL1

Organism: Homo sapiens (Human).

Function: Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Early endosome membrane (By similarity). Golgi apparatus, trans-Golgi network membrane (By similarity). Golgi apparatus membrane (By similarity). Cell projection, axon (By similarity). Cytoplasm, cytoskeleton. Note=Localized to the lateral membrane durin

Protein disease:
Disease database Database Entry Disease information
OMIM600966LETHAL GIANT LARVAE, DROSOPHILA, HOMOLOG OF, 1; LLGL1 ;;LLGL;; HUGL1;; DLG4, FORMERLY
Network with metabolic pathway:
Kegg map ID Pathway Link
map04530Tight junction
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000664
IPR001680
IPR011046
IPR013577
IPR015943