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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Leucine-rich repeat-containing protein 59

UniprotKB/SwissProt ID: LRC59_HUMAN (Q96AG4)

Gene Name: LRRC59

Organism: Homo sapiens (Human).

Function: Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, includi

Protein disease:
Disease database Database Entry Disease information
OMIM614854LEUCINE-RICH REPEAT-CONTAINING PROTEIN 59; LRRC59
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001611

The S-nitrosylation sites of LRC59_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
148LPKATILDLS C NKLTTLPSDF CCCCCEEECC C CCCCCCCHHH 7.28%HC052212679in vitro
248LPKATILDLS C NKLTTLPSDF CCCCCEEECC C CCCCCCCHHH 7.28%HC0519483679in vivo
359NKLTTLPSDF C GLTHLVKLDL CCCCCCCHHH C CCCCCCEEEC 5.39%HC1019483679in vivo
4131DPVLAKVAGD C LDEKQCKQCA HHHHHHHHHH C CCHHHHHHHH 5.16%HC1019483679in vivo