Protein Name: Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
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UniprotKB/SwissProt ID: MACF1_HUMAN (Q9UPN3)
Gene Name: MACF1
Synonyms: ABP620, ACF7, KIAA0465, KIAA1251
Organism: Homo sapiens (Human).
Function: Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Isoform 2: Cytoplasm, cytoskeleton. Cytoplasm. Golgi apparatus. Cell membrane. Cell projection, ruffle membrane. Note=The phosphorylated form is found in the cytoplasm while the non-phosphorylated form associates with the microtubules (By similarity). Lo
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 608271 | MICROTUBULE-ACTIN CROSS-LINKING FACTOR 1; MACF1 ;;MACROPHIN 1;; TRABECULIN-ALPHA;; ACTIN CRO |
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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