UniprotKB/SwissProt ID: MAP1B_MOUSE (P14873)
Gene Name: Map1b
Synonyms: Mtap1b, Mtap5
Organism: Mus musculus (Mouse).
Function: Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing (By similarity). Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton (Probable). Cytoplasm (By similarity). Cell junction, synapse. Cell projection, dendritic spine. Note=Colocalizes with DAPK1 in the microtubules and cortical actin fibers (By similarity).
| |
|
