Protein Name: E3 ubiquitin-protein ligase MARCH5
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UniprotKB/SwissProt ID: MARH5_HUMAN (Q9NX47)
Gene Name: MARCH5
Synonyms: RNF153
Organism: Homo sapiens (Human).
Function: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its presence only in mitochondria (Pu
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 610637 | MEMBRANE-ASSOCIATED RING-CH FINGER PROTEIN 5; MARCH5 ;;MARCH V |
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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