UniprotKB/SwissProt ID: MCAF1_HUMAN (Q6VMQ6)
Gene Name: ATF7IP
Synonyms: MCAF, MCAF1
Organism: Homo sapiens (Human).
Function: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.
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