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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: DNA replication licensing factor MCM3

UniprotKB/SwissProt ID: MCM3_HUMAN (P25205)

Gene Name: MCM3

Organism: Homo sapiens (Human).

Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.

Network with metabolic pathway:
Kegg map ID Pathway Link
map04110Cell cycle
map03030DNA replication
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001208
IPR003593
IPR008046
IPR012340

The S-nitrosylation sites of MCM3_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1148RPKVVRSVHY C PATKKTIERR CEEEEEEEEE E CCCCCEEEEE 0.82%HC092212679in vitro
2148RPKVVRSVHY C PATKKTIERR CEEEEEEEEE E CCCCCEEEEE 0.82%HC0919483679in vivo