Protein Name: DNA replication licensing factor MCM7
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UniprotKB/SwissProt ID: MCM7_HUMAN (P33993)
Gene Name: MCM7
Synonyms: CDC47, MCM2
Organism: Homo sapiens (Human).
Function: Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus (By similarity).
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
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