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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Mitotic spindle assembly checkpoint protein MAD2A

UniprotKB/SwissProt ID: MD2L1_HUMAN (Q13257)

Gene Name: MAD2L1

Synonyms: MAD2

Organism: Homo sapiens (Human).

Function: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore- spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Chromosome, centromere, kinetochore. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Note=Recruited by MAD1L1 to unattached kinetochores (Probable). Recruited to the nuclear pore complex by TPR during interphase. Recruited to kinetochores in l

PDB :
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Network with metabolic pathway:
Kegg map ID Pathway Link
map04110Cell cycle
map04114Oocyte meiosis
map04914Progesterone-mediated oocyte maturation
map05166HTLV-I infection
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR003511

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1DUJ NMR - A11-195Link
1GO4 X-ray 2.05 A A/B/C/D1-205Link
1KLQ NMR - A11-205Link
1S2H NMR - A1-205Link
2QYF X-ray 2.30 A A/C1-205Link
2V64 X-ray 2.90 A A/C/D/E/F/H2-205Link
2VFX X-ray 1.95 A A/B/C/D/E/F/G/H/I/J/K/L1-205Link
3GMH X-ray 3.95 A A/B/C/D/E/F/G/H/I/J/K/L11-205Link

The S-nitrosylation sites of MD2L1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1106VLERWQFDIE C DKTAKDDSAP CEEEEEEEEE C CCCCCCCCCC 7.12%HC1119483679in vivo