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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Monoglyceride lipase

UniprotKB/SwissProt ID: MGLL_MOUSE (O35678)

Gene Name: Mgll

Organism: Mus musculus (Mouse).

Function: Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Network with metabolic pathway:
Kegg map ID Pathway Link
map00561Glycerolipid metabolism
map04723Retrograde endocannabinoid signaling
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000073
IPR003089
IPR008262

The S-nitrosylation sites of MGLL_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
132LVNADGQYLF C RYWKPSGTPK EECCCCCEEE E EEECCCCCCC 2.77%MC0721278135in vitro
232LVNADGQYLF C RYWKPSGTPK EECCCCCEEE E EEECCCCCCC 2.77%MC0722865876in vivo