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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: MARCKS-related protein

UniprotKB/SwissProt ID: MRP_HUMAN (P49006)

Gene Name: MARCKSL1

Synonyms: MLP, MRP

Organism: Homo sapiens (Human).

Function: Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May also affect cancer cell migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be r

PDB :
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Protein disease:
Disease database Database Entry Disease information
OMIM602940MARCKS-LIKE PROTEIN 1; MARCKSL1 ;;MLP;; MARCKS-RELATED PROTEIN; MRP;; MAC-MARCKS;; F52
Network with metabolic pathway:
Kegg map ID Pathway Link
map04666Fc gamma R-mediated phagocytosis
map05140Leishmaniasis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002101