logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Methionine-R-sulfoxide reductase B2, mitochondrial

UniprotKB/SwissProt ID: MSRB2_MOUSE (Q78J03)

Gene Name: Msrb2

Organism: Mus musculus (Mouse).

Function: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post- translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2L1U NMR - A45-175Link

The S-nitrosylation sites of MSRB2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1132ILRRLDTSLG C PRMEVVCKQC   2.04%MC0121278135in vitro
2162DGPKPTGQRF C INSVALKFKP   2.91%MC0121278135in vitro
3162DGPKPTGQRF C INSVALKFKP   2.91%MC0122865876in vivo