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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: S-methyl-5'-thioadenosine phosphorylase

UniprotKB/SwissProt ID: MTAP_MOUSE (Q9CQ65)

Gene Name: Mtap

Organism: Mus musculus (Mouse).

Function: Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00270Cysteine and methionine metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001369
IPR010044

The S-nitrosylation sites of MTAP_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
155LILGKIKNVD C VLLARHGRQH EEEEEECCEE E EEEEECCCCC 1.70%MC0221278135in vitro
2130RPQTFYDGSH C SARGVCHIPM CCCCCCCCCC C CCCCCCCCCC 3.49%MC0520925432in vivo
3130RPQTFYDGSH C SARGVCHIPM CCCCCCCCCC C CCCCCCCCCC 3.49%MC0521278135in vitro