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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Melatonin receptor type 1A

UniprotKB/SwissProt ID: MTR1A_HUMAN (P48039)

Gene Name: MTNR1A

Organism: Homo sapiens (Human).

Function: High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein.

Protein disease:
Disease database Database Entry Disease information
OMIM600665MELATONIN RECEPTOR 1A; MTNR1A ;;MT1
Network with metabolic pathway:
Kegg map ID Pathway Link
map04080Neuroactive ligand-receptor interaction
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000025
IPR000276
IPR002278

The S-nitrosylation sites of MTR1A_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1127NITGIAINRY C YICHSLKYDK HHHHHHHHHH H HHHHHHHHCC 1.34%HC0922178444-
2127NITGIAINRY C YICHSLKYDK HHHHHHHHHH H HHHHHHHHCC 1.34%HC0915978051-
3130GIAINRYCYI C HSLKYDKLYS HHHHHHHHHH H HHHHHCCCCC 0.47%HC1022178444-
4130GIAINRYCYI C HSLKYDKLYS HHHHHHHHHH H HHHHHCCCCC 0.47%HC1015978051-