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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Mucin-2

UniprotKB/SwissProt ID: MUC2_HUMAN (Q02817)

Gene Name: MUC2

Synonyms: SMUC

Organism: Homo sapiens (Human).

Function: Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted. Note=In the intestine, secreted into the inner and outer mucus layers (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map05110Vibrio cholerae infection
map05146Amoebiasis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001007
IPR001846
IPR002919
IPR006207
IPR006208
IPR006552
IPR013032
IPR014853

The S-nitrosylation sites of MUC2_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1263DRCRCPGGDT C VCSTVAEFSR HHHHCCCCCH H HHHHHHHHHH 3.28%HC0125040305in vivo