Protein Name: Unconventional myosin-Ic
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UniprotKB/SwissProt ID: MYO1C_HUMAN (O00159)
Gene Name: MYO1C
Organism: Homo sapiens (Human).
Function: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity). Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Isoform 1: Cytoplasm. Nucleus. Note=Colocalizes with RNA polymerase II. Absent from nucleoli and does not colocalize with RNA polymerase I. Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription. Isoform 2: Cytopl
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 606538 | MYOSIN IC; MYO1C ;;MYOSIN 2, RAT, HOMOLOG OF; MYR2;; NUCLEAR MYOSIN I; NMI |
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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