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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

UniprotKB/SwissProt ID: NDUS6_HUMAN (O75380)

Gene Name: NDUFS6

Organism: Homo sapiens (Human).

Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Protein disease:
Disease database Database Entry Disease information
KEGGH00473 Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (
OMIM252010MITOCHONDRIAL COMPLEX I DEFICIENCY ;;NADH:Q(1) OXIDOREDUCTASE DEFICIENCY;; NADH-COENZYME Q R
OMIM603848NADH-UBIQUINONE OXIDOREDUCTASE Fe-S PROTEIN 6; NDUFS6 ;;COMPLEX I, MITOCHONDRIAL RESPIRATORY
HPRD10356Mitochondrial complex I deficiency
Network with metabolic pathway:
Kegg map ID Pathway Link
map00190Oxidative phosphorylation
map05010Alzheimer's disease
map05012Parkinson's disease
map05016Huntington's disease
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information

The S-nitrosylation sites of NDUS6_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
127AARSLPLGAR C FGVRVSPTGE CCCCCCCCCC E EEEEECCCCC 3.27%HC0224105792-