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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

UniprotKB/SwissProt ID: NDUV2_MOUSE (Q9D6J6)

Gene Name: Ndufv2

Organism: Mus musculus (Mouse).

Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion inner membrane (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00190Oxidative phosphorylation
map05010Alzheimer's disease
map05012Parkinson's disease
map05016Huntington's disease
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002023
IPR012335
IPR012336

The S-nitrosylation sites of NDUV2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1223PKPGPRSGRF C CEPAGGLTSL CCCCCCCCCE E ECCCCCCCCC 2.18%MC0824895380-
2223PKPGPRSGRF C CEPAGGLTSL CCCCCCCCCE E ECCCCCCCCC 2.18%MC0822865876in vivo
3224KPGPRSGRFC C EPAGGLTSLT CCCCCCCCEE E CCCCCCCCCC 6.89%MC1324895380-
4224KPGPRSGRFC C EPAGGLTSLT CCCCCCCCEE E CCCCCCCCCC 6.89%MC1322865876in vivo