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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: NHP2-like protein 1

UniprotKB/SwissProt ID: NH2L1_HUMAN (P55769)

Gene Name: NHP2L1

Organism: Homo sapiens (Human).

Function: Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus, nucleolus. Note=Concentrated in the dense fibrillar component of the nucleolus.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map03008Ribosome biogenesis in eukaryotes
map03040Spliceosome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002415
IPR004037
IPR004038

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1E7K X-ray 2.90 A A/B1-128Link
2JNB NMR - A1-128Link
2OZB X-ray 2.60 A A/D1-128Link
3SIU X-ray 2.63 A A/D1-128Link
3SIV X-ray 3.30 A A/D/G/J1-128Link

The S-nitrosylation sites of NH2L1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
130KKLLDLVQQS C NYKQLRKGAN HHHHHHHHHH H HCCCEEECHH 5.84%HC0619483679in vivo