Protein Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1
|
UniprotKB/SwissProt ID: NHRF1_HUMAN (O14745)
Gene Name: SLC9A3R1
Synonyms: NHERF, NHERF1
Organism: Homo sapiens (Human).
Function: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm (By similarity). Apical cell membrane (By similarity). Endomembrane system; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cell projection, microvillus. Note=Translocates from the cytoplasm to the apical cell
| PDB : ( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. ) |
|
Protein disease:
|
Disease database |
Database Entry |
Disease information | KEGG | H00888 | Nephrolithiasis/osteoporosis, hypophosphatemic | OMIM | 604990 | SOLUTE CARRIER FAMILY 9, MEMBER 3, REGULATOR 1; SLC9A3R1 ;;SODIUM/HYDROGEN EXCHANGER REGULAT | OMIM | 612287 | NEPHROLITHIASIS/OSTEOPOROSIS, HYPOPHOSPHATEMIC, 2 ;;NPHLOP2 |
|
Graphical Visualization of S-nitrosylation Sites:
|
Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
|