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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glutamate receptor ionotropic, NMDA 2A

UniprotKB/SwissProt ID: NMDE1_HUMAN (Q12879)

Gene Name: GRIN2A

Synonyms: NMDAR2A

Organism: Homo sapiens (Human).

Function: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
KEGGH00080 Systemic lupus erythematosus
OMIM138253GLUTAMATE RECEPTOR, IONOTROPIC, N-METHYL-D-ASPARTATE, SUBUNIT 2A; GRIN2A ;;N-METHYL-D-ASPART
OMIM613971EPILEPSY WITH NEURODEVELOPMENTAL DEFECTS; EPND
Network with metabolic pathway:
Kegg map ID Pathway Link
map04720Long-term potentiation
map05014Amyotrophic lateral sclerosis (ALS)
map05030Cocaine addiction
map05033Nicotine addiction
map04724Glutamatergic synapse
map04728Dopaminergic synapse
map05031Amphetamine addiction
map05322Systemic lupus erythematosus
map04020Calcium signaling pathway
map04080Neuroactive ligand-receptor interaction
map05010Alzheimer's disease
map05034Alcoholism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001320
IPR001508
IPR015683

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3NFL X-ray 1.91 A E/F/G/H1449-1464Link

The S-nitrosylation sites of NMDE1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
187TDPKSLITHV C DLMSGARIHG CCHHHHHHHH H HHHCCCCEEE 2.30%HC0922178444-
287TDPKSLITHV C DLMSGARIHG CCHHHHHHHH H HHHCCCCEEE 2.30%HC0912183209-
387TDPKSLITHV C DLMSGARIHG CCHHHHHHHH H HHHCCCCEEE 2.30%HC0917196530-
487TDPKSLITHV C DLMSGARIHG CCHHHHHHHH H HHHCCCCEEE 2.30%HC0917434127-
5320FSYIPEAKAS C YGQMERPEVP CCCCCCCCCC C CCCCCCCCCC 5.45%HC0422178444-
6320FSYIPEAKAS C YGQMERPEVP CCCCCCCCCC C CCCCCCCCCC 5.45%HC0412183209-
7320FSYIPEAKAS C YGQMERPEVP CCCCCCCCCC C CCCCCCCCCC 5.45%HC0417196530-
8320FSYIPEAKAS C YGQMERPEVP CCCCCCCCCC C CCCCCCCCCC 5.45%HC0417434127-
9399VWPRYKSFSD C EPDDNHLSIV CCCCCCCCCC C CCCCCEEEEE 8.72%HC0122178444-
10399VWPRYKSFSD C EPDDNHLSIV CCCCCCCCCC C CCCCCEEEEE 8.72%HC0110571239in vitro
11399VWPRYKSFSD C EPDDNHLSIV CCCCCCCCCC C CCCCCEEEEE 8.72%HC0110607390in vitro
12399VWPRYKSFSD C EPDDNHLSIV CCCCCCCCCC C CCCCCEEEEE 8.72%HC0111092448-
13399VWPRYKSFSD C EPDDNHLSIV CCCCCCCCCC C CCCCCEEEEE 8.72%HC0112183209-
14399VWPRYKSFSD C EPDDNHLSIV CCCCCCCCCC C CCCCCEEEEE 8.72%HC0115688001-
15399VWPRYKSFSD C EPDDNHLSIV CCCCCCCCCC C CCCCCEEEEE 8.72%HC0117434127-