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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: H/ACA ribonucleoprotein complex subunit 3

UniprotKB/SwissProt ID: NOP10_MOUSE (Q9CQS2)

Gene Name: Nop10

Synonyms: Nola3

Organism: Mus musculus (Mouse).

Function: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus, nucleolus (By similarity). Nucleus, Cajal body (By similarity). Note=Also localized to Cajal bodies (coiled bodies) (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map03008Ribosome biogenesis in eukaryotes
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information

The S-nitrosylation sites of NOP10_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
128KKFDPMGQQT C SAHPARFSPD   2.69%MC0220925432in vivo
228KKFDPMGQQT C SAHPARFSPD   2.69%MC0221278135in vitro