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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Dynamin-like 120 kDa protein, mitochondrial

UniprotKB/SwissProt ID: OPA1_MOUSE (P58281)

Gene Name: Opa1

Organism: Mus musculus (Mouse).

Function: Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. Dynamin-like 120 kDa protein, form S1: Inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space.

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001401

The S-nitrosylation sites of OPA1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1375LRMRKNVKEG C TVSPETISLN HHHHHHHCCC C CCCCCEEEEE 3.40%MC0121278135in vitro
2551TRNLSLAVSD C FWKMVRESVE HHHHHHHHHH H HHHHHHHHHH 3.23%MC0221278135in vitro
3551TRNLSLAVSD C FWKMVRESVE HHHHHHHHHH H HHHHHHHHHH 3.23%MC0222865876in vivo
4786MYWKNRTQEQ C VHNETKNELE HHHHCCCHHH H HHHHHHHHHH 3.11%MC1121278135in vitro
5786MYWKNRTQEQ C VHNETKNELE HHHHCCCHHH H HHHHHHHHHH 3.11%MC1122865876in vivo
6874QRHFIDSELE C NDVVLFWRIQ HHHHCCCCCC C CCCHHHHHHH 9.12%MC0822865876in vivo