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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Pyrroline-5-carboxylate reductase 1, mitochondrial

UniprotKB/SwissProt ID: P5CR1_HUMAN (P32322)

Gene Name: PYCR1

Organism: Homo sapiens (Human).

Function: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00330Arginine and proline metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000304
IPR004455

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2GER X-ray 3.10 A A/B/C/D/E1-319Link
2GR9 X-ray 3.10 A A/B/C/D/E1-275Link
2GRA X-ray 3.10 A A/B/C/D/E1-275Link
2IZZ X-ray 1.95 A A/B/C/D/E1-300Link

The S-nitrosylation sites of P5CR1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1262SLLINAVEAS C IRTRELQSMA HHHHHHHHHH H HHHHHHHHHH 2.92%HC0519483679in vivo