Protein Name: Protein kinase C and casein kinase substrate in neurons protein 3
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UniprotKB/SwissProt ID: PACN3_HUMAN (Q9UKS6)
Gene Name: PACSIN3
Organism: Homo sapiens (Human).
Function: Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Detected at the inner aspect of the plasma membrane in myotubes (By similarity).
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Protein disease:
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Disease database |
Database Entry |
Disease information | OMIM | 606513 | PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS 3; PACSIN3 |
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Graphical Visualization of S-nitrosylation Sites:
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Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
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