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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Protein kinase C and casein kinase substrate in neurons protein 3

UniprotKB/SwissProt ID: PACN3_HUMAN (Q9UKS6)

Gene Name: PACSIN3

Organism: Homo sapiens (Human).

Function: Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Detected at the inner aspect of the plasma membrane in myotubes (By similarity).

Protein disease:
Disease database Database Entry Disease information
OMIM606513PROTEIN KINASE C AND CASEIN KINASE SUBSTRATE IN NEURONS 3; PACSIN3
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001060
IPR001452