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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Protein kinase C and casein kinase II substrate protein 3

UniprotKB/SwissProt ID: PACN3_MOUSE (Q99JB8)

Gene Name: Pacsin3

Organism: Mus musculus (Mouse).

Function: Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the inner aspect of the plasma membrane in myotubes.

PDB :
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Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001060
IPR001452

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3M3W X-ray 2.60 A A/B1-320Link
3QE6 X-ray 2.60 A A/B1-304Link
3SYV X-ray 3.10 A A/B/C/D/E/F/G/H1-341Link

The S-nitrosylation sites of PACN3_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1231MEDMEQAFES C QAAERQRLLF HHHHHHHHHH H HHHHHHHHHH 2.22%MC0421278135in vitro
2402KMSEEDEQGW C QGQLQSGRIG EEEEECCCCE E EEEECCCCEE 4.10%MC1321278135in vitro
3421IGLYPANYVE C VGA------- EEEEECCCCE E CCC 2.14%MC1321278135in vitro