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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Protein DJ-1

UniprotKB/SwissProt ID: PARK7_MOUSE (Q99LX0)

Gene Name: Park7

Organism: Mus musculus (Mouse).

Function: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone. May regulate lipid rafts-dependent endocytosis in astrocytes and neuronal cells.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Lipid-anchor. Cytoplasm (By similarity). Membrane raft. Nucleus (By similarity). Mitochondrion (By similarity). Note=Under normal conditions, located predominantly in the cytoplasm and, to a lesser extent, in the nucleus and mitochondrion.

Network with metabolic pathway:
Kegg map ID Pathway Link
map05012Parkinson's disease
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002818
IPR006287

The S-nitrosylation sites of PARK7_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
146AGLAGKDPVQ C SRDVMICPDT EECCCCEEEE E ECCEEEECCC 3.52%MC0622588120-
246AGLAGKDPVQ C SRDVMICPDT EECCCCEEEE E ECCEEEECCC 3.52%MC0619101475-
346AGLAGKDPVQ C SRDVMICPDT EECCCCEEEE E ECCEEEECCC 3.52%MC0620925432in vivo
446AGLAGKDPVQ C SRDVMICPDT EECCCCEEEE E ECCEEEECCC 3.52%MC0621278135in vitro
546AGLAGKDPVQ C SRDVMICPDT EECCCCEEEE E ECCEEEECCC 3.52%MC0622865876in vivo
653PVQCSRDVMI C PDTSLEDAKT EEEEECCEEE E CCCCHHHCCC 1.03%MC0321278135in vitro
753PVQCSRDVMI C PDTSLEDAKT EEEEECCEEE E CCCCHHHCCC 1.03%MC0322865876in vivo
8106ESRKGLIAAI C AGPTALLAHE HHCCCEEEEE C CHHHHHHHHC 2.84%MC1122865876in vivo
9121ALLAHEVGFG C KVTTHPLAKD HHHHHCCCCC C EEEEEECHHH 2.75%MC0322865876in vivo