logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

UniprotKB/SwissProt ID: PDK1_MOUSE (Q8BFP9)

Gene Name: Pdk1

Organism: Mus musculus (Mouse).

Function: Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map04664Fc epsilon RI signaling pathway
map04066HIF-1 signaling pathway
map04660T cell receptor signaling pathway
map04722Neurotrophin signaling pathway
map05145Toxoplasmosis
map05160Hepatitis C
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR003594
IPR005467

The S-nitrosylation sites of PDK1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
171QFLDFGSVNA C EKTSFMFLRQ HHHHCCCCCC C CCHHHHHHHH 4.68%MC0321278135in vitro
2419YKANHEADDW C VPSREPKDMT CCCCCCCCCC C CCCCCCCCCH 4.08%MC0521278135in vitro