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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: PDZ and LIM domain protein 5

UniprotKB/SwissProt ID: PDLI5_HUMAN (Q96HC4)

Gene Name: PDLIM5

Synonyms: ENH

Organism: Homo sapiens (Human).

Function: May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse, synaptosome (By similarity). Cytoplasm (By similarity). Note=Detected both at presynaptic and postsynaptic sites (By similarity).

PDB :
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Protein disease:
Disease database Database Entry Disease information
OMIM605904ENIGMA-LIKE LIM DOMAIN PROTEIN ;;ENIGMA HOMOLOG; ENH
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001478
IPR001781

The S-nitrosylation sites of PDLI5_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1213VPRQPTVTSV C SETSQELAEG CCCCCCCCCC C CCCCCHHHHC 2.81%HC0722178444-