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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Eosinophil peroxidase

UniprotKB/SwissProt ID: PERE_HUMAN (P11678)

Gene Name: EPX

Synonyms: EPER, EPO, EPP

Organism: Homo sapiens (Human).

Function: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.

Protein disease:
Disease database Database Entry Disease information
HPRD00576Eosinophil peroxidase deficiency
Network with metabolic pathway:
Kegg map ID Pathway Link
map05310Asthma
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002007
IPR002016
IPR010255

The S-nitrosylation sites of PERE_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1370LLTNRSARIP C FLAGDTRSTE CCCCCCCCCH H EEECCCCCCC 3.98%HC0425040305in vivo
2635PGARVGPLLA C LFENQFRRAR CCCCCCHHHH H HHHHHHHHHC 4.51%HC1125040305in vivo