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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Phosphoglycerate kinase 1

UniprotKB/SwissProt ID: PGK1_HUMAN (P00558)

Gene Name: PGK1

Synonyms: PGKA

Organism: Homo sapiens (Human).

Function: In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD02412PGK Alabama, hemolytic anemia and mental retardation due to
HPRD02412PGK Amiens, hemolytic anemia due to
HPRD02412PGK Hamamatsu, myopathy and myoglobinura due to
HPRD02412PGK Herlev, hemolytic anemia due to
HPRD02412PGK II
HPRD02412PGK Matsue, nonspherocytic hemolytic anemia due to
HPRD02412PGK Michigan, hemolytic anemia and mental retardation due to
HPRD02412PGK Munchen
HPRD02412PGK Shizuoka, hemolytic anemia and myoglobinuria due to
HPRD02412PGK Tokyo, nonspherocytic hemolytic anemia due to
HPRD02412PGK Uppsala, hemolytic anemia due to
Network with metabolic pathway:
Kegg map ID Pathway Link
map00010Glycolysis / Gluconeogenesis
map04066HIF-1 signaling pathway
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001576
IPR015824
IPR015901
IPR015911

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2WZB X-ray 1.47 A A2-417Link
2WZC X-ray 1.50 A A2-417Link
2WZD X-ray 1.56 A A1-417Link
2X13 X-ray 1.74 A A2-417Link
2X14 X-ray 1.90 A A2-417Link
2X15 X-ray 2.10 A A2-417Link
2XE6 X-ray 1.74 A A1-417Link
2XE7 X-ray 2.20 A A1-417Link
2XE8 X-ray 1.79 A A1-417Link
2Y3I X-ray 2.90 A A/D1-416Link
2YBE X-ray 2.00 A A1-417Link
2ZGV X-ray 2.00 A A1-417Link
3C39 X-ray 1.85 A A/B1-417Link
3C3A X-ray 2.30 A A/B1-417Link
3C3B X-ray 1.80 A A/B1-417Link
3C3C X-ray 2.40 A A/B1-417Link
4AXX X-ray 1.74 A A1-417Link

The S-nitrosylation sites of PGK1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
150IKAAVPSIKF C LDNGAKSVVL HHHHHHHHHH H HHCCCCEEEE 3.86%HC0322178444-
250IKAAVPSIKF C LDNGAKSVVL HHHHHHHHHH H HHCCCCEEEE 3.86%HC0317629318in vitro
350IKAAVPSIKF C LDNGAKSVVL HHHHHHHHHH H HHCCCCEEEE 3.86%HC0318335467-
450IKAAVPSIKF C LDNGAKSVVL HHHHHHHHHH H HHCCCCEEEE 3.86%HC0319366988-
599LGKDVLFLKD C VGPEVEKACA CCCCCEEECC C CCHHHHHHHH 3.49%HC0322178444-
699LGKDVLFLKD C VGPEVEKACA CCCCCEEECC C CCHHHHHHHH 3.49%HC0320140087in vivo
7108DCVGPEVEKA C ANPAAGSVIL CCCCHHHHHH H HCCCCCCEEE 5.79%HC0322178444-
8108DCVGPEVEKA C ANPAAGSVIL CCCCHHHHHH H HCCCCCCEEE 5.79%HC0318335467-
9108DCVGPEVEKA C ANPAAGSVIL CCCCHHHHHH H HCCCCCCEEE 5.79%HC0319366988-
10108DCVGPEVEKA C ANPAAGSVIL CCCCHHHHHH H HCCCCCCEEE 5.79%HC0319483679in vivo
11108DCVGPEVEKA C ANPAAGSVIL CCCCHHHHHH H HCCCCCCEEE 5.79%HC0320140087in vivo
12367DEVVKATSRG C ITIIGGGDTA HHHHHCCCCC C EEEEECCHHH 2.11%HC0322178444-
13379TIIGGGDTAT C CAKWNTEDKV EEEECCHHHH H HHHCCCCCCC 1.65%HC0622178444-
14380IIGGGDTATC C AKWNTEDKVS EEECCHHHHH H HHCCCCCCCC 3.66%HC0522178444-