Protein Name: Polymeric immunoglobulin receptor
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UniprotKB/SwissProt ID: PIGR_HUMAN (P01833)
Gene Name: PIGR
Organism: Homo sapiens (Human).
Function: This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Secretory component: Secreted.
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PDB :
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | OMIM | 173880 | POLYMERIC IMMUNOGLOBULIN RECEPTOR; PIGR ;;POLY-Ig RECEPTOR;; TRANSMEMBRANE SECRETORY COMPONE | | HPRD | 01436 | IgA nephropathy, susceptibility to |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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