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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

UniprotKB/SwissProt ID: PIN4_HUMAN (Q9Y237)

Gene Name: PIN4

Organism: Homo sapiens (Human).

Function: Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. Isoform 2 binds to double-stranded DNA.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Isoform 1: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1. Isoform 2: Mitochondrion. Mitochondrion matrix. Note=Imported in a time

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000297

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1EQ3 NMR - A36-131Link
1FJD NMR - A30-131Link
3UI4 X-ray 0.80 A A36-131Link
3UI5 X-ray 1.40 A A36-131Link
3UI6 X-ray 0.89 A A36-131Link

The S-nitrosylation sites of PIN4_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
145GNAVKVRHIL C EKHGKIMEAM CEEEEEEEEE E CCHHHHHHHH 6.91%HC0419483679in vivo