UniprotKB/SwissProt ID: PLEC_HUMAN (Q15149)
Gene Name: PLEC
Synonyms: PLEC1
Organism: Homo sapiens (Human).
Function: Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofibers integrity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell junction, hemidesmosome.
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