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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Plasminogen

UniprotKB/SwissProt ID: PLMN_MOUSE (P20918)

Gene Name: Plg

Organism: Mus musculus (Mouse).

Function: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity). Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted (By similarity). Note=Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map04610Complement and coagulation cascades
map05150Staphylococcus aureus infection
map04080Neuroactive ligand-receptor interaction
map05164Influenza A
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000001
IPR001254
IPR001314
IPR003014
IPR003609
IPR003966
IPR009003
IPR011358
IPR013806