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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Pre-mRNA branch site protein p14

UniprotKB/SwissProt ID: PM14_HUMAN (Q9Y3B4)

Gene Name: SF3B14

Organism: Homo sapiens (Human).

Function: Necessary for the splicing of pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (Potential).

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map03040Spliceosome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000504
IPR012677

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2F9D X-ray 2.50 A A/B1-125Link
2F9J X-ray 3.00 A A/B1-125Link
2FHO NMR - B8-93Link
3LQV X-ray 2.38 A A/B11-125Link

The S-nitrosylation sites of PM14_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
174YEDIFDAKNA C DHLSGFNVCN ECCHHHHHHH H HHHCCCEECC 4.78%HC0419483679in vivo
283ACDHLSGFNV C NRYLVVLYYN HHHHHCCCEE C CEEEEEEECC 2.23%HC0119483679in vivo