Protein Name: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
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UniprotKB/SwissProt ID: PP2AA_MOUSE (P63330)
Gene Name: Ppp2ca
Organism: Mus musculus (Mouse).
Function: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus (By similarity). Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole (By similarity). Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles (By similarity
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
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