logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

UniprotKB/SwissProt ID: PP2AA_MOUSE (P63330)

Gene Name: Ppp2ca

Organism: Mus musculus (Mouse).

Function: PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus (By similarity). Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole (By similarity). Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles (By similarity

Network with metabolic pathway:
Kegg map ID Pathway Link
map04728Dopaminergic synapse
map04730Long-term depression
map05142Chagas disease (American trypanosomiasis)
map05160Hepatitis C
map03015mRNA surveillance pathway
map04114Oocyte meiosis
map04151PI3K-Akt signaling pathway
map04350TGF-beta signaling pathway
map04530Tight junction
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR004843
IPR006186

The S-nitrosylation sites of PP2AA_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
120LDQWIEQLNE C KQLSESQVKS HHHHHHHHHH C CCCCHHHHHH 3.11%MC0321278135in vitro
2133ITQVYGFYDE C LRKYGNANVW HHHHHHHHHH H HHHCCCHHHH 3.99%MC0622865876in vivo
3196LQEVPHEGPM C DLLWSDPDDR CCCCCCCCCC E EEECCCCCCC 3.62%MC1321278135in vitro
4251HQLVMEGYNW C HDRNVVTIFS HHHHHHHHHH H HCCCEEEEEE 1.81%MC1221278135in vitro
5266VVTIFSAPNY C YRCGNQAAIM EEEEEECCCH H HCCCCCEEEE 1.88%MC0621278135in vitro
6266VVTIFSAPNY C YRCGNQAAIM EEEEEECCCH H HCCCCCEEEE 1.88%MC0622865876in vivo
7269IFSAPNYCYR C GNQAAIMELD EEECCCHHHC C CCCEEEEEEE 2.13%MC1321278135in vitro