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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

UniprotKB/SwissProt ID: PP2BA_RAT (P63329)

Gene Name: Ppp3ca

Synonyms: Calna

Organism: Rattus norvegicus (Rat).

Function: Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1 (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane (By similarity). Cell membrane, sarcolemma (By similarity). Nucleus (By similarity). Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map04720Long-term potentiation
map05014Amyotrophic lateral sclerosis (ALS)
map04210Apoptosis
map04360Axon guidance
map04370VEGF signaling pathway
map04380Osteoclast differentiation
map04650Natural killer cell mediated cytotoxicity
map04660T cell receptor signaling pathway
map04662B cell receptor signaling pathway
map04724Glutamatergic synapse
map04728Dopaminergic synapse
map05031Amphetamine addiction
map04010MAPK signaling pathway
map04020Calcium signaling pathway
map04114Oocyte meiosis
map04310Wnt signaling pathway
map05010Alzheimer's disease
map05152Tuberculosis
map05166HTLV-I infection
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR004843
IPR006186

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
4IL1 X-ray 3.00 A A/B/C/D1-492Link

The S-nitrosylation sites of PP2BA_RAT

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1228FKEPPAYGPM C DILWSDPLED CCCCCCCCHH H HHHHCCCCCC 3.11%RC0216418269in vitro