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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Lysophosphatidic acid phosphatase type 6

UniprotKB/SwissProt ID: PPA6_HUMAN (Q9NPH0)

Gene Name: ACP6

Synonyms: ACPL1, LPAP

Organism: Homo sapiens (Human).

Function: Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion.

Network with metabolic pathway:
Kegg map ID Pathway Link
map00740Riboflavin metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000560

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
4JOB X-ray 2.17 A A33-428Link
4JOC X-ray 2.21 A A33-428Link
4JOD X-ray 2.21 A A33-428Link

The S-nitrosylation sites of PPA6_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1175NIFRNLESTR C LLAGLFQCQK CCHHHHHHHH H HHHHHCCCCC 3.56%HC1119483679in vivo
2183TRCLLAGLFQ C QKEGPIIIHT HHHHHHHHCC C CCCCCCCCCC 4.97%HC0519483679in vivo