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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Peptidyl-prolyl cis-trans isomerase F, mitochondrial

UniprotKB/SwissProt ID: PPIF_MOUSE (Q99KR7)

Gene Name: Ppif

Organism: Mus musculus (Mouse).

Function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress- induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map05145Toxoplasmosis
map04020Calcium signaling pathway
map05012Parkinson's disease
map05016Huntington's disease
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002130
IPR015891

The S-nitrosylation sites of PPIF_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1103TFHRVIPAFM C QAGDFTNHNG EEEEECCCCE E ECCCCCCCCC 1.71%MC0121278135in vitro
2103TFHRVIPAFM C QAGDFTNHNG EEEEECCCCE E ECCCCCCCCC 1.71%MC0122865876in vivo
3156PNTNGSQFFI C TIKTDWLDGK CCCCCCEEEE E CCCCCCCCCC 2.45%MC1221278135in vitro
4156PNTNGSQFFI C TIKTDWLDGK CCCCCCEEEE E CCCCCCCCCC 2.45%MC1222865876in vivo
5202KTSKKIVITD C GQLS------ CCCCCEEEEE C CCCC 2.54%MC0121278135in vitro
6202KTSKKIVITD C GQLS------ CCCCCEEEEE C CCCC 2.54%MC0121930693
(Cys203)
in vivo