UniprotKB/SwissProt ID: PPM1B_HUMAN (O75688)
Gene Name: PPM1B
Synonyms: PP2CB
Organism: Homo sapiens (Human).
Function: Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser- 172'. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Membrane (By similarity). Note=Weakly associates at the membrane and N- myristoylation mediates the membrane localization (By similarity).
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