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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Protein phosphatase methylesterase 1

UniprotKB/SwissProt ID: PPME1_MOUSE (Q8BVQ5)

Gene Name: Ppme1

Synonyms: Pme1

Organism: Mus musculus (Mouse).

Function: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000073
IPR000639
IPR003089
IPR008262

The S-nitrosylation sites of PPME1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1238RVSMVGQVKQ C EGITSPEGSK HHHHHHHHHH H HHHCCHHHHH 4.24%MC0921278135in vitro
2312FRGLSNLFLS C PIPKLLLLAG CCCCCCCCCC C CCCEEEEEEC 3.73%MC0720925432in vivo
3312FRGLSNLFLS C PIPKLLLLAG CCCCCCCCCC C CCCEEEEEEC 3.73%MC0721278135in vitro