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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Peroxiredoxin-1

UniprotKB/SwissProt ID: PRDX1_HUMAN (Q06830)

Gene Name: PRDX1

Synonyms: PAGA, PAGB, TDPX2

Organism: Homo sapiens (Human).

Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04146Peroxisome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000866
IPR012335
IPR012336

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2RII X-ray 2.60 A A/B1-199Link
3HY2 X-ray 2.10 A A/B1-199Link

The S-nitrosylation sites of PRDX1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
152FFYPLDFTFV C PTEIIAFSDR EEECCCCCCC C HHHHHHHHHH 2.77%HC0714559909-
252FFYPLDFTFV C PTEIIAFSDR EEECCCCCCC C HHHHHHHHHH 2.77%HC0723796488-
352FFYPLDFTFV C PTEIIAFSDR EEECCCCCCC C HHHHHHHHHH 2.77%HC0712033427-
452FFYPLDFTFV C PTEIIAFSDR EEECCCCCCC C HHHHHHHHHH 2.77%HC0717519234-
552FFYPLDFTFV C PTEIIAFSDR EEECCCCCCC C HHHHHHHHHH 2.77%HC0715683743-
6173FQFTDKHGEV C PAGWKPGSDT HHHHHHCCEE C CCCCCCCCCC 1.34%HC0714559909-
7173FQFTDKHGEV C PAGWKPGSDT HHHHHHCCEE C CCCCCCCCCC 1.34%HC0723796488-
8173FQFTDKHGEV C PAGWKPGSDT HHHHHHCCEE C CCCCCCCCCC 1.34%HC0712033427-
9173FQFTDKHGEV C PAGWKPGSDT HHHHHHCCEE C CCCCCCCCCC 1.34%HC0717519234-
10173FQFTDKHGEV C PAGWKPGSDT HHHHHHCCEE C CCCCCCCCCC 1.34%HC072212679in vitro
11173FQFTDKHGEV C PAGWKPGSDT HHHHHHCCEE C CCCCCCCCCC 1.34%HC0715683743-
12173FQFTDKHGEV C PAGWKPGSDT HHHHHHCCEE C CCCCCCCCCC 1.34%HC0718335467-
13173FQFTDKHGEV C PAGWKPGSDT HHHHHHCCEE C CCCCCCCCCC 1.34%HC0719366988-
14173FQFTDKHGEV C PAGWKPGSDT HHHHHHCCEE C CCCCCCCCCC 1.34%HC0720140087in vivo