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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Peroxiredoxin-1

UniprotKB/SwissProt ID: PRDX1_MOUSE (P35700)

Gene Name: Prdx1

Synonyms: Msp23, Paga, Tdpx2

Organism: Mus musculus (Mouse).

Function: Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Regulates GDPD5 function by reducing an intramolecular disulfide bond (By similarity). Cooperates with GDPD5 to drive postmitotic motor neuron differentiation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Melanosome (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map04146Peroxisome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000866
IPR012335
IPR012336

The S-nitrosylation sites of PRDX1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
171DRADEFKKLN C QVIGASVDSH HHHHHHHHCC C EEEEEECCCH 5.04%MC0822865876in vivo
283VIGASVDSHF C HLAWINTPKK EEEEECCCHH H HHHHHHHHHH 1.84%MC0322865876in vivo
3173FQFTDKHGEV C PAGWKPGSDT HHHHHHCCEE C CCCCCCCCCC 1.34%MC0422588120-
4173FQFTDKHGEV C PAGWKPGSDT HHHHHHCCEE C CCCCCCCCCC 1.34%MC0420925432in vivo
5173FQFTDKHGEV C PAGWKPGSDT HHHHHHCCEE C CCCCCCCCCC 1.34%MC0421278135in vitro
6173FQFTDKHGEV C PAGWKPGSDT HHHHHHCCEE C CCCCCCCCCC 1.34%MC0422865876in vivo