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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Proteasome subunit alpha type-1

UniprotKB/SwissProt ID: PSA1_MOUSE (Q9R1P4)

Gene Name: Psma1

Organism: Mus musculus (Mouse).

Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal macrophage proteasome. Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map03050Proteasome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000426
IPR001353

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3UNB X-ray 2.90 A E/S/g/u1-263Link
3UNE X-ray 3.20 A E/S/g/u1-263Link
3UNF X-ray 2.90 A E/S1-263Link
3UNH X-ray 3.20 A E/S1-263Link

The S-nitrosylation sites of PSA1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
185AGLTADARLL C NFMRQECLDS ECCHHHHHHH H HHHHHHHHHH 4.34%MC0721278135in vitro
292RLLCNFMRQE C LDSRFVFDRP HHHHHHHHHH H HHHHHHCCCC 3.76%MC0321278135in vitro
3182LERHMSEFME C NLDELVKHGL HHHHCCCCCC C CHHHHHHHHH 4.04%MC0122865876in vivo