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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Proteasome subunit alpha type-7

UniprotKB/SwissProt ID: PSA7_MOUSE (Q9Z2U0)

Gene Name: Psma7

Organism: Mus musculus (Mouse).

Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions (By similarity). The interaction with EMAP2 increases the proteasome-mediated HIF- 1A degradation under the hypoxic conditions (By similarity). Promotes MAVS degradation and thereby negatively regulates MAVS- mediated innate immune response (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map03050Proteasome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000426
IPR001353

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3UNB X-ray 2.90 A C/Q/e/s1-248Link
3UNE X-ray 3.20 A C/Q/e/s1-248Link
3UNF X-ray 2.90 A C/Q1-248Link
3UNH X-ray 3.20 A C/Q1-248Link

The S-nitrosylation sites of PSA7_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
163LQDERTVRKI C ALDDNVCMAF CCCCCCCCCE E EECCEEEEEE 3.27%MC0920925432in vivo