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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: 26S proteasome non-ATPase regulatory subunit 4

UniprotKB/SwissProt ID: PSMD4_HUMAN (P55036)

Gene Name: PSMD4

Synonyms: MCB1

Organism: Homo sapiens (Human).

Function: Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map03050Proteasome
map05169Epstein-Barr virus infection
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002035
IPR003903

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1P9C NMR - A263-307Link
1P9D NMR - S263-307Link
1UEL NMR - B263-307Link
1YX4 NMR - A196-306Link
1YX5 NMR - A196-306Link
1YX6 NMR - A196-306Link
2KDE NMR - A196-306Link
2KDF NMR - A196-306Link

The S-nitrosylation sites of PSMD4_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
137QAQQDAVNIV C HSKTRSNPEN HHHHHHHHHH H HHHHCCCCCC 2.38%HC0619483679in vivo
287TVQPKGKITF C TGIRVAHLAL CCCCCCCEEE H HHHHHHHHHH 2.26%HC1019483679in vivo