UniprotKB/SwissProt ID: PTBP1_HUMAN (P26599)
Gene Name: PTBP1
Synonyms: PTB
Organism: Homo sapiens (Human).
Function: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus.
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PDB :
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