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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Tyrosine-protein phosphatase non-receptor type 6

UniprotKB/SwissProt ID: PTN6_HUMAN (P29350)

Gene Name: PTPN6

Synonyms: HCP, PTP1C

Organism: Homo sapiens (Human).

Function: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04520Adherens junction
map04650Natural killer cell mediated cytotoxicity
map04660T cell receptor signaling pathway
map04662B cell receptor signaling pathway
map05140Leishmaniasis
map04630Jak-STAT signaling pathway
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000242
IPR000387
IPR000980
IPR012152

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1FPR X-ray 2.50 A A243-526Link
1GWZ X-ray 2.50 A A243-541Link
1X6C NMR - A110-214Link
2B3O X-ray 2.80 A A1-532Link
2RMX NMR - A110-214Link
2YU7 NMR - A110-214Link
3PS5 X-ray 3.10 A A1-595Link
4GRY X-ray 1.70 A A243-528Link
4GRZ X-ray 1.37 A A243-528Link
4GS0 X-ray 1.80 A A/B243-528Link
4HJP X-ray 1.40 A A243-528Link
4HJQ X-ray 1.80 A A/B243-528Link

The S-nitrosylation sites of PTN6_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1453LPHAGPIIVH C SAGIGRTGTI CCCCCCEEEE C CCCCCHHHHH 1.75%HC0222178444-
2453LPHAGPIIVH C SAGIGRTGTI CCCCCCEEEE C CCCCCHHHHH 1.75%HC0215684422-