UniprotKB/SwissProt ID: RAB14_HUMAN (P61106)
Gene Name: RAB14
Organism: Homo sapiens (Human).
Function: Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side (By similarity). Golgi apparatus, trans- Golgi network membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, p
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PDB :
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